Two-stage mTPI design is for lower target toxicity rate.1. Decision Table:Two decision tables are generated based on marginal beta distribution. The first table is generated based on the beta distribution of severe toxicity probability. The second table is generated based on the beta distribution of mild/moderate toxicity probability Sample size (N) is the total number of sample Target severe toxicity rate is an upper threshold for the probability of severe toxicity at MTD Target mild/moderate toxicity rate is an upper threshold for the probability of mild/moderate toxicity at MTD2. Find the MTD (Maximum Tolerated Dose):When the trials are finished, the pool adjacent violators algorithm (pava) are used to find the MTD Input the number of severe toxicity patients and the number of treated patients at each dose except for unacceptable dose level as well as target toxicity rate

Dose level

No. of severe toxicity (x2)

No. of patients (n)

No. of severe toxicity (x2)

No. of patients (n)